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目的：观察迁延性腹泻患儿血锌变化及口服葡萄糖酸锌治疗的临床疗效。方法对105例迁延性腹泻(病程≥2周)患儿进行血锌检测,并与同期进行健康体检的正常儿童和同期住院的急性腹泻患儿的血锌值进行对照。将105例迁延性腹泻患儿随机分为观察组53例和对照组52例,对照组采用综合治疗(肠黏膜保护剂、微生态疗法、纠正代谢紊乱和脱水,有细菌感染者使用敏感抗生素,加强营养支持,指导饮食等),观察组在对照组基础上加用葡萄糖酸锌口服液,3~7 d为1个疗程。观察两组治疗效果、止泻时间及总疗程。结果迁延性腹泻组血锌值(60.48±9.61)mg/L,低于急性腹泻组(73.75±10.67)mg/L,差异有统计学意义(P<0.01)；急性腹泻组血锌值低于正常组(87.53±13.41)mg/L,差异有统计学意义(P<0.01)。观察组总有效率83.0%(44/53)高于对照组59.6%(31/52),差异有统计学意义(P<0.01)。观察组止泻时间和总疗程也短于对照组,差异有统计学意义(P<0.01)。结论迁延性腹泻患儿锌缺乏程度比急性腹泻患儿更严重,合理补充微量元素锌是治疗迁延性腹泻病经济可行的方法。“,”objective to observe changes in persistent diarrhea in children with blood zinc and zinc gluconate oral clinical curative ef ect of treatment. Methods 105 cases of children with persistent diarrhea ( a course of 2 weeks or more) is used to detect the blood zinc, and physical examination over the same period of normal children in the hospital and the comparing the blood zinc value of children with acute diarrhea. 105 cases of children with persistent diarrhea were randomly divided into observation group and 53 cases of 52 cases and control group, control group adopts comprehensive treatment ( intestinal mucosa protectant, micro ecological therapy, correcting metabolic disorder, and dehydration, a sensitive bacteria infection using antibiotics and nutri-tion support, diet guidance, etc. ) , the observation group in the control group on the basis of the total zinc gluconate oral liquid, 3 ~ 7 d for a course of treatment. Observe two groups of treat-ment ef ect, antidiarrheal time and total course of treatment. Results persistent diarrhea group blood zinc value of mg/L (60. 48 + 9. 61), lower than that of acute diarrhea group (73. 75 + /- 10. 67 mg/L, the dif erence was statistical y significant (P < 0. 01);Acute diarrhea blood zinc value is lower than normal group (87. 53 + / - 13. 41 mg/L, the dif erence was statistical y significant(P < 0.01). Observationgrouptotalefectiveratewas83.0% (44/53)higherthanthecontrolgroup83.0% (31/52),thediferencewasstatisticalysignificant(P < 0.01). Observation group antidiarrheal time and total course is shorter than the control group, the dif erence was statistical y significant (P < 0. 01). Conclusion persistent diarrhea in children with zinc deficiency more serious than children with acute diarrhea, rational supplement of trace element zinc is in the treatment of persistent diarrhea disease economic and feasible method.