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本文报道6例下丘脑性闭经(HA)不孕者,年龄为21～34岁,经克罗米酚和中医中药治疗无效,改用在自动输液泵控制下经静脉脉冲输注GnRII诱发排卵.结果在2.5～6.25μg/90min剂量下治疗2个周期(23～36天)无反应,而当剂量增至10～20μg/90min时,9个治疗周期(11～23天)中7个周期有直径大于18mm真的优势卵泡发育,4例妊娠.3个hMG脉冲治疗周期(14～20天)(4.9375～18.75U/90min,皮下)均出现了多卵泡发育.
This article reports 6 cases of hypothalamic amenorrhea (HA) infertility, aged 21 to 34 years old, the treatment of clomiphene and traditional Chinese medicine ineffective, switched to the use of automatic infusion pump controlled intravenous infusion of GnRII induced ovulation. Results There was no response in two cycles (23-36 days) at doses of 2.5-6.25μg / 90min. When the dosage was increased to 10-20μg / 90min, there were 7 cycles in 9 cycles (11-23 days) Follicles with a diameter greater than 18 mm really developed, and 4 pregnancies. Three hMG cycles (14-20 days) (4.9375 ~ 18.75U / 90min, subcutaneous) showed multiple follicles.