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本文实验报告谷氨酸能增强巨噬细胞对石英的细胞毒作用的抵抗力;口服谷氨酸钠能抑制气管内注入石英粉尘所引起的矽肺发展。实验采用粒径小于5μ的DQ_(12)标准石英粉尘和大鼠腹腔内注入凡士林油48～65小时后所获得的腹模巨噬细胞,分别与25、50和500μg/ml的谷氨酸预先孵育,然后再用各种不同浓度的石英粉尘混悬液在37℃环境中孵育,借2.3.5—三苯基四唑化氯(2.3.5,-
In this paper, we report that glutamate enhances the resistance of macrophages to the cytotoxic effect of quartz. Oral sodium glutamate can inhibit the development of silicosis caused by intratracheal instillation of quartz dust. Experiments were performed using DQ 12 standard quartz dust with a particle size of less than 5μ and abdominal macrophages obtained from 48 to 65 hours after intraperitoneal injection of petrolatum in rats with 25, 50 and 500 μg / ml glutamic acid, respectively Incubated with various concentrations of quartz dust suspension at 37 ° C and incubated with 2.3.5-triphenyltetrazolium chloride (2.3.5, -