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异丁基哌嗪力复霉素(简称R_(76-1))系由力复霉素SV加侧链哌嗪异丁醇而成的新半合成抗生素。经过多年的体外抗菌作用研究。临床前药理研究和临床试用,均证实R_(76-1)具有抗菌谱广,作用强,毒付反应小的优点,特别是对结核,麻疯杆菌具有较强的抗菌作用与利福平相比具有抗菌力强,对肝脏损害小,价格便宜的特点,是一种较理想的新抗结核药。实验结果: 一、肠胃道吸收实验:采用分别结扎胃,空肠、迥肠各注入定量的~3HR76—1测其残留量,求其吸收剩余百分数,结果是1小时后胃中剩余83％,空肠68％,迥肠61％,3小时后
Isobutylpiperazine rifamycins (referred to as R_ (76-1)) is a new semi-synthetic antibiotics made by the addition of vicugin SV plus side-chain piperazine isobutyl alcohol. After many years of in vitro antibacterial research. Preclinical pharmacological studies and clinical trials have confirmed that R_ (76-1) has the advantages of wide antibacterial spectrum, strong action and little poisonous reaction, especially to tuberculosis and leptospira, which has strong antibacterial activity and rifampicin Than with antimicrobial power, damage to the liver, the characteristics of cheap, is a more ideal new anti-TB drugs. Experimental results: First, the gastrointestinal absorption test: respectively ligation of the stomach, jejunum, colostomy each injected quantitative ~ 3HR76-1 measured its residual amount, and asked the remaining percentage absorption, the result is 1 hour after the remaining 83% of the stomach, the jejunum 68%, 61% of colon, 3 hours later