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目的:探讨慢萎颗粒对高原地区慢性萎缩性胃炎(CAG)患者氨基己糖(HS)、表皮生长因子(EGF)水平的影响。方法:选择符合CAG伴异型增生(Dys)和(或)肠化生(IM),中医辨证属气虚血瘀的患者共80例,随机分为治疗组40例,对照组40例。治疗组采用慢萎颗粒口服,对照组采用摩罗丹口服,用药6周。观察两组治疗前后临床症状、胃黏膜病理的变化,检测两组治疗前后胃液HS及EGF水平变化。结果:慢萎颗粒在缓解萎缩性胃炎患者临床症状方面较摩罗丹组明显为好;在改善胃镜下异型增生及肠化方面明显优于摩罗丹组;能明显降低萎缩性胃炎黏膜EGF水平;能明显提高萎缩性胃炎黏膜HS水平。结论:慢萎颗粒能较好的缓解萎缩性胃炎患者的临床症状,改善胃镜下胃黏膜病理组织异性增生及肠化生,能提高萎缩性胃炎黏膜HS水平,降低萎缩性胃炎黏膜EGF水平。
Objective: To investigate the effects of chronic wasting granule on the levels of hexosamine (HS) and epidermal growth factor (EGF) in patients with chronic atrophic gastritis (CAG) in the plateau. Methods: Eighty patients with Cys with dysplasia (Dys) and / or intestinal metaplasia (IM) were selected and randomly divided into treatment group (40 cases) and control group (40 cases). The treatment group was treated with slow wilt particles, the control group was orally administered with morotan for 6 weeks. The clinical symptoms and pathological changes of gastric mucosa were observed before and after treatment. The levels of HS and EGF in gastric juice were measured before and after treatment. Results: Slow wilt particles in the treatment of atrophic gastritis in patients with clinical symptoms were significantly better than the Morinda group; to improve dysplasia and intestinal metaplasia was significantly better than the morotan group; can significantly reduce the atrophic gastritis mucosal EGF level; can Significantly improve atrophic gastritis mucosal HS levels. Conclusion: ZWH can alleviate the clinical symptoms of patients with atrophic gastritis, improve gastric mucosal dysplasia and intestinal metaplasia under endoscopy, increase the HS level of atrophic gastritis mucosa, and reduce the EGF level of atrophic gastritis.