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Single-event effects (SEEs) induced by medium-energy protons in a 28 nm system-on-chip (SoC) were investigated at the China Institute of Atomic Energy. An on-chip memory block was irradiated with 90 MeV and 70 MeV protons, respectively. Single-bit upset and multi-cell upset events were observed, and an uppermost number of nine upset cells were discovered in the 90 MeV proton irradiation test. The results indicate that the SEE sensitiv-ities of the 28 nm SoC to the 90 MeV and 70 MeV protons were similar. Cosmic Ray Effects on Micro-Electronics Monte Carlo simulations were analyzed, and it demon-strates that protons can induce effects in a 28 nm SoC if their energies are greater than 1.4 MeV and that the lowest correspondinglinearenergytransferwas 0.142 MeV cm2 mg-1. The similarities and discrepancies of the SEEs induced by the 90 MeV and 70 MeV protons were analyzed.