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颗粒细胞瘤(granulosa cell tumor,GCT),属于性索间质肿瘤,呈低度恶性,预后良好,但是有晚期复发的特点。GCT病因不明,目前研究集中于基因甲基化、染色体微卫星不稳定等方面。22号染色单体和14号染色三体的异常多见。治疗以手术为主,但由于GCT有晚期复发的特点,因此,应特别强调足够的化疗疗程及各期患者应终身随访。
Granulosa cell tumor (GCT), which belongs to the sex cord stromal tumor, is of low grade and has a good prognosis, but has the characteristics of late recurrence. GCT etiology is unknown, the current study focused on gene methylation, chromosome microsatellite instability and so on. Abnormalities of chromosome 22 and 14 were noticed. The treatment is surgery-based, but due to the characteristics of advanced recurrent GCT, special emphasis should be placed on adequate course of chemotherapy and lifelong follow-up of all patients.