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目的:对长链非编码小核仁RNA宿主基因（SNHGs）在胃癌组织中的表达水平与胃癌患者的预后及临床病理特征的关系进行荟萃分析。方法:通过PubMed、Embase、Web of science、万方数据库和中国知网数据库（截至2019年12月30日）进行文献检索、筛选及数据提取后，应用RevMan 5.3软件对纳入研究数据进行荟萃分析。结果:最终24项研究包括2280名患者纳入本荟萃分析。根据SNHGs的表达程度与胃癌的关系，我们将SNHGs分为表达上/下调基因组两组。经过数据分析，上调基因组高表达的胃癌患者总生存期较短（合并n HR=1.84，95% n CI 1.54~2.20，n P<0.001）；下调基因组低表达的胃癌患者总生存期较短（合并n HR=0.53，95% n CI 0.35~0.80，n P=0.002）。同时，SNHGs的表达异常与胃癌患者较短的无病生存期及较晚的TNM分期相关。n 结论:SNHGs的表达水平与胃癌患者的预后及临床病理特征密切相关，可作为胃癌早期诊断、靶向治疗及个体化治疗的关键靶点。“,”Objective:To evaluate the association between SNHGs, prognosis and clinicopathological parameters in patients with gastric cancer.Methods:Eligible studies were gathered from Web of Science, PubMed, Embase, WanFang databases and China National Knowledge Infrastructure. The data were analyzed by the RevMan software.Result:24 studies included 2280 patients in this meta-analysis. After data analysis, the high expression of up-regulated gene was related to the shorter survival period of cancer patients (n HR=1.84, 95% n CI 1.54-2.20, n P<0.001) ; the low expression of down-regulated gene was related to the shorter survival period of gastric cancer patients (n HR=0.53, 95% n CI 0.35-0.80, n P=0.002) . The abnormal expression of SNHGs was closely related to shorter disease-free survival period and later TNM stage of tumor.n Conclusion:The expression level of SNHGs is closely related to the prognosis and clinicopathological characteristics of gastric cancer patients, which is a potential biomarker and therapeutic target for gastric cancers.