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目的 :探讨口腔鳞癌组织中Ⅳ型胶原 (ColⅣ )及层粘连蛋白 (LN)含量的变化与临床病理参数的关系。方法 :应用放射免疫技术测定 30例口腔鳞癌及 6例正常口腔粘膜组织抽提液中ColⅣ及LN的含量 ,并对其与临床病理参数的关系进行统计学分析。结果 :肿瘤组织中ColⅣ及LN含量分别为 1 83± 0 2 1μg/ml和 1 0 2± 0 11μg/ml,而正常组织分别为 2 87± 0 45 μg/ml及 1 98± 0 2 3μg/ml,两组比较 ,分别为P <0 0 5和P <0 0 1;肿瘤组织中ColⅣ和LN含量的变化与病理分级及肿瘤部位无关 ,而与是否有颈淋巴结转移和浸润方式有关。结论 :测量口腔鳞癌组织中ColⅣ和LN含量对判断口腔鳞癌有无转移和预后有一定价值。
Objective: To investigate the relationship between the changes of collagen Ⅳ (Col Ⅳ) and laminin (LN) in oral squamous cell carcinoma and clinicopathological parameters. Methods: The contents of ColⅣ and LN in 30 oral squamous cell carcinomas and 6 normal oral mucosa tissue extracts were determined by radioimmunoassay. The relationship between Col Ⅳ and LN was analyzed with clinicopathological parameters. Results: The contents of Col Ⅳ and LN were 1 83 ± 0 2 1 μg / ml and 1 0 2 ± 0 11 μg / ml respectively in normal tissues, while those in normal tissues were 2 87 ± 0 45 μg / ml and 1 98 ± 0 2 3 μg / ml respectively, P <0.05 and P <0.01, respectively. The changes of ColⅣ and LN in the tumor tissue were not related to the pathological grade and tumor location, but were related to the metastasis of cervical lymph nodes and the infiltration of tumor. Conclusion: The determination of Col Ⅳ and LN levels in oral squamous cell carcinoma has some value in judging the metastasis and prognosis of oral squamous cell carcinoma.