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目的研究利巴韦林气雾剂在改善手足口病患儿临床症状及病毒阴转率中的作用。方法 86例手足口病患儿,随机分成观察组与对照组,各43例。两组患儿均采用抗病毒口服液进行辅助治疗,在此基础上观察组患儿给予利巴韦林气雾剂治疗,对照组患儿给予安慰剂进行治疗。治疗7 d后对两组患儿治疗前后的症状情况以及病毒阴转率进行比较。结果观察组患儿的总肠道病毒以及肠道病毒71型(EV71)的阴转率均高于对照组,差异具有统计学意义(P<0.05);两组患儿的柯萨奇病毒A组16型(CA16)阴转率比较差异无统计学意义(P>0.05)。治疗7 d后,观察组患儿口腔溃疡及皮疹治疗总有效率分别为97.67%、97.67%,均显著高于对照组的62.79%、76.74%,差异有统计学意义(P<0.05)。结论利巴韦林气雾剂在改善手足口病患儿临床症状方面的效果显著,且能够提高病毒的阴转率,促进患儿尽快康复。
Objective To study the effect of ribavirin aerosol in improving clinical symptoms and virus negative rate in children with hand-foot-mouth disease. Methods 86 cases of hand, foot and mouth disease were randomly divided into observation group and control group, 43 cases in each group. Both groups of children were treated with antiviral oral liquid adjuvant therapy, on the basis of observation group children given ribavirin aerosol treatment, control group of children given placebo for treatment. After 7 days of treatment, the symptoms of the two groups of children before and after treatment and the virus negative conversion rate were compared. Results The negative rate of total enterovirus and EV71 in the observation group were significantly higher than those in the control group (P <0.05). Coxsackievirus A Group 16 (CA16) negative conversion rate was no significant difference (P> 0.05). After 7 days of treatment, the total effective rate of oral ulcer and rash in the observation group was 97.67% and 97.67%, respectively, which were significantly higher than those in the control group (62.79% and 76.74%, respectively) (P <0.05). Conclusion Ribavirin aerosol has significant effect in improving the clinical symptoms of HFMD children, and can improve the virus negative conversion rate and promote the recovery of children as soon as possible.