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目的 :研究 SARS定点医院不同岗位工作人员白细胞分类及红细胞天然免疫黏附功能 (erythrocyte innate imm uneadhesion function,EIIAF)的变化 ,了解 SARS定点医院医务人员生理机能的变化。方法 :将研究对象分成 5组 ,分别为 SARS定点医院门诊检验人员组、SARS一线人员组、非 SARS病区人员组、医院机关人员组以及院外对照组。对以上各组人员分别进行白细胞分类及 EIIAF测定。SARS特异性 Ig G抗体的检测采用 EL ISA法。结果 :SARS定点医院各组人员的白细胞总数显著高于院外对照组 (P<0 .0 5 ,P<0 .0 1 ) ;SARS一线人员和门诊检验人员的 EIIAF显著低于非 SARS病区人员和机关人员(P<0 .0 1 ) ,其中有 37.5 %的 SARS一线人员的 EIIAF低于正常人平均水平。 6位参与重症 SARS抢救而无显性发病的医务人员 EIIAF全部处于高表达水平 (与正常人群平均水平比较 ,P<0 .0 5 )。结论 :SARS环境中的工作人员机体处于应激状态 ,与 SARS密切接触的一线人员机体存在免疫清除过程 ,亚健康状态可能是 SARS相关医务人员易感的重要原因之一。
Objective: To study the classification of white blood cells (WBC) and the erythrocyte innate imm uneadhesion function (EIAF) of staff in different positions in the designated hospital of SARS to understand the changes of the physiology and function of medical staff in designated hospitals of SARS. Methods: The subjects were divided into five groups, namely SARS designated hospital outpatient laboratory staff, SARS front-line staff, non-SARS ward staff, hospital staff and hospital control group. The above groups of people were leukocyte classification and EIIAF determination. The SARS-specific Ig G antibody was detected by the EL ISA method. Results: The total number of white blood cells in each group of SARS fixed-point hospitals was significantly higher than that of the control group (P0.05, P0.01). The EIIAF of first-line SARS patients and outpatients was significantly lower than that of non-SARS patients (P <0.01). Among them, 37.5% of the SARS front-line workers had EIIAF lower than the normal average level. EIIAF was significantly higher in all 6 medical staff who participated in the rescue of SARS than in the normal population (P <0.05). CONCLUSIONS: In the SARS environment, the staff members are in stress state. The first-line human body in close contact with SARS has immunodepletion process. Sub-health status may be one of the important causes of SARS-related medical staff’s susceptibility.