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目的探讨C-反应蛋白(CRP)、降钙素原(PCT)及血小板(PLT)联合检测对早期预判新生儿细菌性败血症的临床价值。方法选取信阳市中心医院新生儿败血症患儿91例为观察组,新生儿缺氧缺血性脑病(无感染、先天畸形等)患儿91例作为对照组。观察分析CRP、PCT及PLT三项检测指标,比较对照组与观察组治疗前、恢复期的动态变化;绘制受试者工作特征曲线,确定CRP、PCT及PLT的最佳截断值,计算其灵敏度及特异度。结果观察组治疗前CRP、PCT及PLT检测指标均高于对照组,且治疗前CRP、PCT及PLT均高于恢复期,差异有统计学意义(P<0.05);CRP、PCT及PLT三项联合检测指标敏感性高达94.87%,特异性高达91.10%。结论 CRP、PCT与PLT联合检测的结果对早期诊断新生儿败血症具有较高的敏感性及特异性,联合应用可提高新生儿败血症诊断的准确性。
Objective To investigate the clinical value of combined detection of C-reactive protein (CRP), procalcitonin (PCT) and platelet (PLT) in early prediction of bacterial septicemia in neonates. Methods 91 cases of neonatal sepsis in Xinyang Central Hospital were selected as the observation group, 91 cases of neonates with hypoxic-ischemic encephalopathy (no infection, congenital malformations, etc.) as control group. Observed and analyzed CRP, PCT and PLT three indicators to compare the control group and observation group before and during the recovery of the dynamic changes; draw the working curve of the subjects to determine the optimal cut-off value of CRP, PCT and PLT to calculate the sensitivity And specificity. Results Before treatment, the indexes of CRP, PCT and PLT in observation group were higher than those in control group, and the levels of CRP, PCT and PLT before treatment were higher than those of recovery period, the difference was statistically significant (P <0.05); CRP, PCT and PLT Joint detection index sensitivity up to 94.87%, specificity up to 91.10%. Conclusion The combined detection of CRP, PCT and PLT has high sensitivity and specificity for the early diagnosis of neonatal sepsis. The combination of CRP, PCT and PLT can improve the diagnostic accuracy of neonatal sepsis.