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目的:探讨子宫内膜癌组织中survivin(存活素)蛋白和VEGF(血管内皮生长因子)表达及其意义。方法:运用免疫组织化学S-P法,检测20例正常子宫内膜组织、20例不典型增生子宫内膜和63例子宫内膜癌组织中survivin蛋白和VEGF的表达,并结合临床病理特点进行分析。结果:survivin蛋白、VEGF的阳性表达率在正常子宫内膜组织、不典型增生子宫内膜、子宫内膜癌中逐渐升高,三者之间有显著性差异(x2=24.97,P<0.01;x2=18.65,P<0.01)。在子宫内膜癌中,survivin蛋白的表达与组织学分级和手术-病理分期密切相关(x2=9.20,P<0.05;x2=20.60,P<0.01);VEGF的表达与组织学分级无关(x2=4.93,P>0.05),而与手术-病理分期分期密切相关(x2=38.10,P<0.01)。survivin表达与VEGF表达呈显著正相关(r=0.257;p<0.05)。结论:survivin、VEGF分别通过抑制细胞凋亡、诱导新生血管的形成而影响子宫内膜癌的发生和发展,其在子宫内膜癌的发生中可能存在协同作用。
Objective: To investigate the expression of survivin (survivin) and VEGF (vascular endothelial growth factor) in endometrial carcinoma and its significance. Methods: The expressions of survivin protein and VEGF in 20 cases of normal endometrium, 20 cases of atypical hyperplasia endometrium and 63 cases of endometrial carcinoma were detected by immunohistochemical S-P method and analyzed according to clinicopathological features. Results: The positive expression rate of survivin protein and VEGF in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma were significantly higher than those in normal endometrium (x2 = 24.97, P <0.01; x2 = 18.65, P <0.01). In endometrial carcinoma, the expression of survivin was closely related to histological grade and operation-pathological stage (x2 = 9.20, P <0.05; x2 = 20.60, P <0.01) = 4.93, P> 0.05), but closely related to the stage of surgery-pathology (x2 = 38.10, P <0.01). There was a significant positive correlation between survivin expression and VEGF expression (r = 0.257; p <0.05). CONCLUSIONS: Survivin and VEGF may affect the occurrence and development of endometrial carcinoma by inhibiting apoptosis and inducing neovascularization, respectively. There may be synergistic effects in the pathogenesis of endometrial carcinoma.