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目的:探讨老年肿瘤患者的细胞免疫功能,为临床免疫增强治疗提供理论依据。方法:采用流式细胞仪分别检测80例老年肿瘤患者和60例正常老年人外周血淋巴细胞免疫表型,并对两组进行比较。结果:与对照组比较,肿瘤患者CD3+、CD4+、NK、CD4+/CD8+比值、CD19+细胞比例降低具有统计学意义(P<0.05)。CD8+比例增高具有统计学意义(P<0.05)。结论:肿瘤患者免疫功能较正常对照组比较明显降低,外周血淋巴细胞免疫表型分析可作为临床肿瘤患者常规免疫功能检测的一种方法,为临床应用免疫增强治疗提供理论依据。
Objective: To investigate the cellular immune function in elderly patients with cancer and provide a theoretical basis for clinical immune enhancement therapy. Methods: The immunophenotypes of peripheral blood lymphocytes in 80 elderly patients with cancer and 60 normal controls were detected by flow cytometry. The two groups were compared. Results: Compared with the control group, the proportion of CD3 +, CD4 +, NK, CD4 + / CD8 + and CD19 + cells in the tumor patients decreased significantly (P <0.05). The proportion of CD8 + increased with statistical significance (P <0.05). CONCLUSION: The immune function of tumor patients is significantly lower than that of normal control group. Immunophenotyping of peripheral blood lymphocytes can be used as a routine immunological function test in clinical cancer patients, providing a theoretical basis for clinical application of immune enhancement therapy.