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目的 :通过动物实验观察冬凌草含片长期应用的安全性。方法 :取 6周龄大鼠 6 0只 ,随机均分为冬凌草含片高剂量 (40g/kg)组、低剂量 (2 0g/kg)组、生理盐水组。每天灌药 1次 ,每 7天称重量 1次 ,据此调整药量 ,连续用药 2 1天。检查大鼠血常规、肝、肾功能 ;取大鼠心、肝、脾、肺、肾、胃、肠、脑、睾丸 (卵巢 )作组织切片。结果 :对大鼠自主活动、饮食、体重均无不良影响 ,各项实验室检查未见异常 ,组织学检查均为正常。结论 :冬凌草含片长期服用 ,对大鼠无明显不良反应。
Objective : To observe the safety of long-term application of Donglingcao lozenges through animal experiments. Methods: Sixty six-week-old rats were randomly divided into high dose (40g/kg) group, low dose (20g/kg) group, and normal saline group. Dosing once a day, weighing once every 7 days, according to which adjust the dose, continuous medication for 21 days. The rats were examined for blood routine, hepatic and renal function; the heart, liver, spleen, lung, kidney, stomach, intestine, brain, and testis (ovarian) were taken for tissue sectioning. Results: There were no adverse effects on the rats’ autonomic activity, diet, and body weight. No abnormalities were found in all laboratory tests, and histological examinations were normal. Conclusion : There was no obvious adverse reaction to the rats after being used for a long period of time.