论文部分内容阅读
风湿性疾病泛指影响骨、关节及周围软组织,如肌腱、滑囊、筋膜等一组疾病,而药物是治疗风湿性疾病的重要手段,风湿性疾病常用的治疗药物包括镇痛药、非甾体抗炎药、皮质类固醇类药、缓解病情风湿药及生物制剂,但部分患者在治疗开始或期间就对药物不敏感,除了疾病自身的特点外,个体遗传因素也是一个重要的影响因素。风湿性疾病药物基因组学的研究进展可预测药物治疗的效果和不良反应,并可为临床治疗提供合理的指导和建议。本文以风湿性疾病常用的治疗药物为主线,归纳了近年来影响药物疗效中有关药物代谢酶、药物转运体和药物作用靶点的基因组学研究进展。
Rheumatic diseases generally refers to a group of diseases that affect the bones, joints and surrounding soft tissues, such as tendons, bursa, fascia and the like, and drugs are an important means of treating rheumatic diseases. Commonly used therapeutic drugs for rheumatic diseases include analgesics, Steroidal anti-inflammatory drugs, corticosteroids, rheumatism drugs and biological agents to alleviate the disease, but some patients are not sensitive to drugs at the beginning or during treatment. Apart from the characteristics of the disease, individual genetic factors are also an important factor. Advances in the research of pharmacogenomics of rheumatic diseases can predict the efficacy and adverse reactions of drug therapy and provide reasonable guidance and advice for clinical treatment. In this paper, the treatment of rheumatic diseases commonly used drugs as the main line, summed up in recent years, the impact of drug efficacy in drug metabolism enzymes, drug transporters and drug target of progress in genomics.