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问:何种剂型及剂量的阿司匹林适用于治疗短暂性脑缺血?答:当阿司匹林用作抗血小板剂时,剂量适合可减轻溃疡。美国有资料认为最佳剂量是每日75mg,另有提出每日1～25mg,亦常有用300mg。然而,通常赞同最低有效剂量应该是保持副作用最轻,但更重要的是高剂量可抵销由于血管中前列环素合成抑制引起的血栓素 A_2合成抑制。前列环素本身可抑制血小板凝集。肠溶型阿司匹林由于纤维素外壳 introduct-ion 而使其溶解度及生物利用度增加。有外壳的片剂与无外壳的片剂相比较,在相同剂量下可达到近似的
Q: What dosage and dosage aspirin is suitable for transient ischemic attack? A: When aspirin is used as an anti-platelet agent, the dosage is suitable to reduce the ulcer. The United States has the information that the best dose is 75mg daily, while the other proposed daily 1 ~ 25mg, often useful 300mg. However, it is generally agreed that the lowest effective dose should be to maintain the lightest side effects, but more importantly, high doses can counteract thromboxane A_2 synthesis inhibition due to inhibition of prostacyclin synthesis in the blood vessels. Prostacyclin itself inhibits platelet aggregation. Enteric-coated aspirin increases its solubility and bioavailability due to the introduction of cellulose sheaths. Encapsulated tablets can be approximated at the same dosage as tablets without the outer shell