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患者为女性,67岁,下肢出现斑丘疹,血液学常规及骨髓检查均正常。2个月后躯干及上肢出现皮肤结节,白细胞33.6×10~9/l,分类87%为幼稚细胞,骨髓中充满白血病细胞,经组织化学和单克隆抗体检测诊断为急性粒-单核细胞白血病,皮肤活检为单核细胞浸润。化疗完全缓解后皮肤结节消退。两周后又出现皮肤广泛浸润,活检符合单纯皮肤白血病,而骨髓检查却正常。采用阿糖胞苷100mg皮下注射,每日2次,连用5天及6-TG口服治疗,1周内皮肤损害
The patient was female, age 67, with rash on lower extremities, routine hematology and bone marrow tests. Twenty-four months later, the skin and nodules of the trunk and upper extremity appeared. The number of white blood cells was 33.6 × 10 ~ 9 / l, and 87% were immature cells. The bone marrow was full of leukemia cells and was diagnosed as acute granular monocytic cells by histochemistry and monoclonal antibody Leukemia, skin biopsy monocyte infiltration. Skin nodules subsided after chemotherapy was completely relieved. Two weeks later there was extensive skin infiltration, biopsy consistent with simple skin leukemia, and bone marrow examination was normal. Cytarabine 100mg subcutaneously twice a day for 5 days and 6-TG oral treatment, 1 week skin damage