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目的:探讨血小板源性生长因子受体(PDGFR)的表达与肾细胞癌之间的关系。方法:应用免疫组化SP法检测12例正常肾、14癌旁组织、46例肾细胞癌组织中PDGFR的表达,并结合肾癌的分级、分期和随访结果进行研究。结果:PDGFR表达于细胞膜、细胞浆和核膜;肾癌组织表达阳性率为73.91%,明显高于正常组织及癌旁组织,统计学有显著性差异(P<0.05);PDGFR的表达在肾癌的分级中有显著性差异(P<0.05),而在分期中无显著性差异(P>0.05),与肾癌5年生存率无相关关系(P>0.05)。结论:PDGFR的过度表达与肾癌的发生密切相关;PDGFR的表达未能作为肾癌生物学行为指标。
Objective: To investigate the relationship between the expression of platelet-derived growth factor receptor (PDGFR) and renal cell carcinoma. Methods: The expression of PDGFR in 12 cases of normal renal tissues, 14 adjacent tissues and 46 cases of renal cell carcinoma was detected by immunohistochemical SP method. Combined with the classification, staging and follow-up results of renal cell carcinoma. Results: The positive expression rate of PDGFR in cell membrane, cytoplasm and nuclear membrane was 73.91%, which was significantly higher than that in normal tissues and paracancerous tissues (P <0.05). The expression of PDGFR in kidney There was significant difference in the grade of carcinoma (P <0.05), but no significant difference in staging (P> 0.05), but not with the 5-year survival rate of renal cell carcinoma (P> 0.05). Conclusion: The overexpression of PDGFR is closely related to the development of renal cell carcinoma. The expression of PDGFR can not be used as a biological indicator of renal cell carcinoma.