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检测125例KDP患者血脂谱、随机血糖、HbA1c、胰岛功能(CP)、KAD-Ab。任意抗体阳性为A+,3种抗体均为阴性为A-,空腹FCP≥0.3333nmol/L为β+,反之为β-。根据检测结果将研究对列分为4组。结果A+β-组发病年龄最轻,BMI、CP水平最低,HDL显著高于A-β+、A-β-(P<0.01)。A-β+组发病年龄最大,BMI最高,TG水平显著升高(P<0.05),而空腹C肽水平显著高于其他组(P<0.01)。A+β+组和A-β-组临床特征介于A+β-组和A-β-组之间。结论以酮症起病的糖尿病患者根据胰岛自身免疫抗体和B细胞功能客人提示其临床表型亚型,提示应根据不同临床特点采取不同的治疗。
Blood lipid profile, random blood glucose, HbA1c, islet function (CP) and KAD-Ab were detected in 125 KDP patients. Any antibody was positive for A +, all three antibodies were negative for A-, fasting FCP ≥ 0.3333nmol / L for β +, whereas it was β-. Based on the test results, the study was divided into four groups. Results The age of onset was the lightest in A + β-thallus, the lowest in BMI and CP, and the HDL was significantly higher than that in A-β + and A-β- (P <0.01). A-β + group had the highest age of onset, the highest BMI and TG (P <0.05), while the fasting C peptide was significantly higher than the other groups (P <0.01). The clinical features of A + β + group and A-β- group were between A + β-group and A-β-group. Conclusion Diabetic patients with ketosis suggest that their clinical phenotypes are subtypes based on islet autoimmune antibodies and functional B-cell guests, suggesting that different treatments should be taken according to different clinical features.