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目的 探讨强直性脊椎炎 (AS)患者HLA -B2 7的检测意义。方法 2 0 0 2年 3月至 2 0 0 2年 9月 ,因关节病前来诊断的患者 2 76例 ,用单抗板淋巴细胞毒法测其白细胞上的HLA -B2 7抗原。结果 确诊为AS的患者中HLA -B2 7阳性率 96.3 % (119 12 4)显著高于非AS的病人的HLA -B2 7阳性率 2 .2 % (3 15 2 ) (P <0 .0 0 1) ,B2 7阴性AS患者发病年龄高于B2 7阳性患者 ,且男性多于女性 ,男女发病年龄相比无统计学意义。结论 HLA -B2 7与强直性脊椎炎有很强的关联性 ,对于长期不明原因的腰腿痛患者结合临床及X线HLA -B2 7可作为AS的早期诊断和鉴别诊断指标。
Objective To investigate the significance of HLA-B2 7 in patients with ankylosing spondylitis (AS). Methods From March 2006 to September 2002, 76 cases of patients diagnosed as arthropathies were tested for HLA-B2 7 antigens on leukocytes by the monoclonal antibody lymphotoxin method. Results The positive rate of HLA-B2 7 was 96.3% (119 12 4) in patients diagnosed as AS, which was significantly higher than that of non-AS patients (2.2%, 3.2%, 3 15 2) 1). The age of onset of B2 7-negative AS patients was higher than that of B2 7-positive patients, and there were more males than females. There was no significant difference in age of onset between men and women. Conclusion HLA-B2 7 has strong correlation with ankylosing spondylitis. Combined with clinical and X-ray HLA-B2 7 can be used as an early diagnosis and differential diagnosis of AS in long-term unexplained patients with low back pain.