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淋病依然是上海地区最常见的性传播疾病之一。虽然其诊断和治疗不难,但由于某些患者不规则用药以及细菌本身的变异,将导致耐药菌株的出现。为监测本地区淋病流行概况及淋球菌耐药变化,更好地为临床医师提供合理用药方案,对上述情况实施连续追踪监测有重要意义。本文就上海市淋病发病情况及淋球菌对抗生素敏感性监测做5年追踪分析,报告如下。 1 病例与方法 1.1 临床监测 本文病例来自1995年1月～1999年12月上海市性病防治中心(现上海市皮肤病性病医院)门诊及各区、县性病监测中心分别汇总的病人。 1.1.1 方法:用棉拭子从男性病人尿道内3～4cm处、女性病人宫颈管内1cm处取材。并接种于TM淋菌培养基分离,置含5％CO_2的35℃孵箱中培养24～48h,以菌落形态、菌体形态和氧化酶试验均阳性鉴定为淋球菌。纯培养后,置脱脂牛奶中,-70℃保存备用。
Gonorrhea is still one of the most common sexually transmitted diseases in Shanghai. Although its diagnosis and treatment is not difficult, due to the irregular medication of some patients and the mutation of bacteria itself, the emergence of drug-resistant strains will result. In order to monitor the epidemic situation of Gonorrhea and the change of Neisseria Gonorrhoeae in this area, it is of great importance to provide clinicians with a reasonable drug regimen for continuous follow-up monitoring. This article on the incidence of gonorrhea in Shanghai and gonococcal sensitivity monitoring of antibiotics to do 5-year follow-up analysis, the report is as follows. 1 cases and methods 1.1 clinical monitoring of this case from January 1995 to December 1999 Shanghai STD Center (now Shanghai Dermatology Hospital) outpatient and district, county STD monitoring center were summarized patients. 1.1.1 Methods: cotton swab from the male patient urethra 3 ~ 4cm Department, female patients within 1cm of the cervical canal drawn. And inoculated in TM gonococcus culture medium, containing 5% CO 2 35 ℃ incubator incubated 24 ~ 48h, the colony morphology, cell morphology and oxidase test were positive for Neisseria gonorrhoeae. Pure culture, set skim milk, -70 ℃ save spare.