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目的:探讨维吾尔族2型糖尿病颈动脉粥样硬化相关的危险因素。方法:收集2003-01/2005-05在新疆医科大学第一附属医院收治的146例维吾尔族2型糖尿病患者,进行颈动脉B超检查,测定内中膜厚度及有无粥样硬化斑块,以内中膜厚度>度1.2mm为斑块形成标准。记录临床资料,计算体质量指数,测定糖化血红蛋白、血压、总胆固醇、三酰甘油、高、低密度脂蛋白胆固醇、脂蛋白α、凝血酶原时间、活化部分凝血酶原时间、凝血酶时间和纤维蛋白原。结果:146例全部完成测试进入结果分析。①颈动脉粥样硬化的检出率为51.8%,146例根据有无颈动脉粥样硬化分为2组:粥样硬化组76例和非粥样硬化组70例。②粥样硬化组年龄、病程、总胆固醇、低密度脂蛋白胆固醇、纤维蛋白原显著高于非粥样硬化组[(57.75±3.46),(51.21±3.23)岁;(5.52±0.58),(4.45±0.43)年;(4.72±0.47),(4.21±0.56)mmol/L;(3.29±0.53),(2.33±0.45)mmol/L;(4.52±0.76)(3.49±0.49)g/L;P均<0.05]。③多元Logistic回归分析显示,年龄、低密度脂蛋白胆固醇、纤维蛋白原进入方程,且OR值均大于1,P<0.01。结论:年龄、低密度脂蛋白胆固醇和纤维蛋白原是维吾尔族2型糖尿病颈动脉粥样硬化的独立危险因素。
Objective: To investigate the risk factors associated with carotid atherosclerosis in Uygur type 2 diabetes mellitus. Methods: A total of 146 Uighur type 2 diabetic patients were enrolled in the First Affiliated Hospital of Xinjiang Medical University from January 2003 to May 2005. The carotid artery B-ultrasound was performed to determine the intima-media thickness and the presence of atherosclerotic plaque. Medial thickness> 1.2mm for plaque formation criteria. Clinical data were recorded and body mass index was calculated. HbA1c, blood pressure, total cholesterol, triglyceride, high and low density lipoprotein cholesterol, lipoprotein α, prothrombin time, activated partial prothrombin time, thrombin time and Fibrinogen. Results: All 146 cases completed the test and entered the result analysis. ① The detection rate of carotid atherosclerosis was 51.8%, 146 cases were divided into two groups based on the presence or absence of carotid atherosclerosis: 76 cases of atherosclerosis and 70 cases of non-atherosclerosis. ②The age, course of disease, total cholesterol, low density lipoprotein cholesterol, fibrinogen in atherosclerosis group were significantly higher than those in non-atherosclerotic group (57.75 ± 3.46, 51.21 ± 3.23, 5.52 ± 0.58, 4.45 ± 0.43 years; 4.72 ± 0.47 and 4.21 ± 0.56 mmol / L; 3.29 ± 0.53 and 2.33 ± 0.45 mmol / L respectively; and (4.52 ± 0.76) and (3.49 ± 0.49) g / P <0.05]. (3) Multivariate Logistic regression analysis showed that age, LDL cholesterol and fibrinogen entered the equation with OR values above 1, P <0.01. Conclusion: Age, low density lipoprotein cholesterol and fibrinogen are independent risk factors for carotid atherosclerosis in Uygur type 2 diabetes mellitus.