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新发现的一类细胞凋亡抑制蛋白 (IAPs) ,其特殊的分子结构及抑制细胞凋亡的功能正日益引起人们的关注。发现IAPs与肿瘤、神经细胞凋亡等疾病有关 ,IAPs有可能作为靶蛋白为这些疾病的治疗开辟新路径。1 IAPs的生物学结构和功能1993年Crook等[1 ] 首先发现并从杆状病毒中分离出
A newly discovered class of apoptosis-inhibiting proteins (IAPs) is attracting more and more attention because of its special molecular structure and the function of inhibiting apoptosis. IAPs were found to be associated with diseases such as cancer and neuronal apoptosis. IAPs may open up new pathways for the treatment of these diseases as target proteins. 1 biological structure and function of IAPs 1993 Crook et al [1] first found and isolated from the baculovirus