论文部分内容阅读
目的 研究食管原发小细胞癌的临床病理特征及其组织发生。方法 采用免疫组织化学方法。结果 单纯小细胞癌７ 例，中间细胞型４ 例，混合型３ 例。免疫组织化学上，细胞角蛋白阳性１０ 例，上皮膜抗原阳性１２ 例，ＮＳＥ阳性１３ 例，嗜铬粘蛋白Ａ阳性６ 例，突触素阳性４ 例。随访病例中６ 例在半年内死亡。结论 本研究证明食管小细胞癌是一种高度恶性的肿瘤，组织发生上支持来自全能干细胞。
Objective To study the clinicopathological features and histogenesis of primary small cell carcinoma of esophagus. Methods Immunohistochemical methods were used. Results There were 7 cases of simple small cell carcinoma, 4 cases of intermediate cell type, and 3 cases of mixed type. In immunohistochemistry, cytokeratin was positive in 10 cases, epithelial membrane antigen was positive in 12 cases, NSE was positive in 13 cases, chromogranin A was positive in 6 cases, and synaptophysin was positive in 4 cases. Six of the follow-up cases died within six months. Conclusion This study demonstrates that small cell esophageal cancer is a highly malignant tumor that supports tissue-derived totipotent stem cells.