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目的:本研究拟运用静息态功能磁共振成像探讨皮质下脑卒中患者运动想象有关脑区功能连接状况。方法:对24例病灶位于左侧运动通路的皮质下脑卒中患者和年龄、性别相匹配的24例正常对照进行静息态脑功能磁共振成像扫描,以病变侧(左侧)顶下小叶为种子点,计算它与其他脑区的功能连接,利用双样本t检验对比分析两组受试者静息态功能连接差异。结果:与正常对照比较,脑卒中组的运动想象相关脑区之间功能连接发生显著变化。脑卒中组病变侧顶下小叶与病变对侧脑功能连接显著下降,涉及的脑区(顶下小叶、辅助运动皮质、运动前区、额下回岛盖部和枕中回)多于病变同侧(辅助运动皮质和运动前区);顶下小叶与病变同侧的额下回岛盖部和双侧小脑外侧部的功能连接显著增加。结论:静息态磁共振成像功能连接分析成功显示皮质下脑卒中导致运动想象相关脑区功能连接受损的客观存在。
Objective: In this study, resting state functional magnetic resonance imaging (FMRI) is proposed to explore the functional connectivity of brain regions related to motor imaging in patients with subcortical stroke. Methods: Twenty-four patients with subcortical stroke who were located in the left motor path and 24 normal controls matched for age and sex were subjected to resting state functional magnetic resonance imaging (FMRI) scan. The top and bottom of the lesion (left) The seed points were calculated for functional connectivity with other brain regions, and the differences in resting functional connectivity between the two groups were compared by two-sample t-test. Results: Compared with the normal control group, there was a significant change in functional connectivity between brain regions related to motor imaging in stroke group. In the stroke group, there was a significant decrease in the contralateral brain function connection between the parietal lobule and lesion, involving more brain regions (parietal lobule, motor cortex, pre-motor area, lower back cover and midcapsular area) than lesions Side (assist motor cortex and pre-motor area); a significant increase in functional connectivity between the inferior epicardial subthalamic roof and bilateral lateral cerebellar portions of the parietal lobule and lesion. Conclusions: Resting state magnetic resonance imaging functional connectivity analysis successfully demonstrated the objective existence of subcortical stroke leading to impaired functional connectivity in motor-related brain regions.