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目的:证据显示内皮祖细胞(EPCs)含两亚群即CD34~+-EPCs和CD14~+-EPCs。之前评估EPCs与冠心病关系的研究并没有区分CD34~+-EPCs和CD14~+-EPCs这两类细胞或只纳入了CD34~+-EPCs。因此本研究探索了CD14~+-EPCs数量与冠心病及心血管危险因素的关系。方法:100例患者入选(对照组34例,稳定性冠心病组41例,急性冠脉综合征组25例),CD14~+-EPCs定义为表面标记CD14阳性和血管内皮生长因子受体-2(KDR)阳性细胞,用流式细胞仪检测其数量。结果:3组间CD14~+-EPCs水平差异无统计学意义;CD14~+-EPCs数量与冠状动脉严重程度或危险因素也无关。结论:CD14~+-EPCs水平与冠心病严重程度或心血管危险因素无关。
PURPOSE: Evidence shows that endothelial progenitor cells (EPCs) contain two subpopulations of CD34 + -EPCs and CD14 + -EPCs. Previous studies assessing the association between EPCs and coronary heart disease did not distinguish between CD34 + -EPCs and CD14 + -EPCs or only CD34 + -EPCs. Therefore, this study explored the relationship between the number of CD14 ~ + -EPCs and coronary heart disease and cardiovascular risk factors. Methods: 100 patients were enrolled (34 in control group, 41 in stable coronary artery disease group and 25 in acute coronary syndrome group). CD14 + -EPCs were defined as surface marker CD14 positive and vascular endothelial growth factor receptor 2 (KDR) positive cells, the number of flow cytometry. Results: There was no significant difference in the level of CD14 + -EPCs between the three groups. The number of CD14 + -EPCs also had no correlation with the severity of coronary artery or risk factors. Conclusion: The level of CD14 + -EPCs has nothing to do with the severity of coronary heart disease or cardiovascular risk factors.