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为应对骨缺损修复过程中的细菌感染问题,利用原位法制备了具有药物缓释功能的纳米羟基磷灰石(n-HA)和壳聚糖(CS)复合微球,并与纯CS载药微球和共混法n-HA/CS复合载药微球进行对比研究。利用相差显微镜和扫描电镜对微球进行形貌观察,结果显示原位法复合载药微球表面形态和球形度均较好。对载药微球的载药率、药物包封率和体外药物释放进行了测试和分析,结果表明原位法复合载药微球载药率和药物包封率最高,分别为(0.3907±0.0203)%和(7.4221±0.3858)%,并具有明显的缓释效果。
In order to cope with the problem of bacterial infection in the process of bone defect repair, nano-hydroxyapatite (n-HA) and chitosan (CS) composite microspheres with sustained drug release were prepared by in situ method. Drug microspheres and blending n-HA / CS drug-loaded microspheres for comparative study. Morphology observation of microspheres by phase contrast microscopy and scanning electron microscopy showed that the morphologies and sphericity of microspheres in situ were better. The drug-loading rate, drug entrapment efficiency and in vitro drug release of drug-loaded microspheres were tested and analyzed. The results showed that the drug loading rate and drug entrapment efficiency of the drug-loaded microspheres in situ were the highest (0.3907 ± 0.0203 )% And (7.4221 ± 0.3858)%, respectively, with obvious sustained-release effect.