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本文应用研究慢性支气管炎的动物模型,评价大鼠接触SO_2后气管和支气管的粘液滞留和细胞学改变。用体重为125～225g的雌性大鼠在SO_2浓度为600～700ppm、气流速度为27l/分的接触室中,每天吸入SO_2小时,一周六天。在吸入累计时间分别为0、9、18和30小时后,将实验和对照动物麻醉、开胸、抽血至完全处死。收集气管内全部粘液和作支气管灌洗,离心后检查所得固体物质(细胞和非细胞)的量,染色后作支气管杯状细胞计数。结果见表。
In this paper, animal models of chronic bronchitis were used to evaluate mucus retention and cytology in trachea and bronchus after exposure to SO 2. Female rats weighing 125-225 g were inhaled SO 2 hours daily for six days a week in a contact chamber having an SO 2 concentration of 600-700 ppm and an air flow rate of 27 l / min. After a cumulative inhalation time of 0, 9, 18 and 30 hours, respectively, experimental and control animals were anesthetized, thoracotomy, and blood drawn to complete sacrifice. Collect all mucus in the trachea and bronchial lavage, and check the amount of solid material (cells and non-cells) obtained after centrifugation, bronchial goblet cell count after staining. The results shown in the table.