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目的 初步探讨全身炎症反应在体外循环术后脑损伤中的作用。方法 体外循环下心内直视手术的瓣膜病或先心病 40例 ,在体外循环中和体外循环结束后不同时间点采血测定血浆S10 0蛋白浓度 ,同时检测血浆TNF、IL 6、IL 8、ET 1的浓度 ,并观测患者术后神经系统并发症。结果 体外循环可引起患者血浆S10 0蛋白的明显升高 ,体外循环结束时的浓度与血浆炎症因子明显相关 ,体外循环后 8h血浆S10 0蛋白的高浓度与炎症反应相平行。结论 全身炎症反应在体外循环中和术后早期的脑损伤中占有重要地位。
Objective To investigate the role of systemic inflammatory response in brain injury after cardiopulmonary bypass. Methods Forty patients with valvular heart disease or congenital heart disease under cardiopulmonary bypass undergoing cardiopulmonary bypass were enrolled in this study. Plasma S10 0 concentration was measured at different time points after cardiopulmonary bypass and after cardiopulmonary bypass. TNF, IL 6, IL 8, ET 1 The patients were followed up for neurological complications. Results Extracorporeal circulation induced a significant increase of plasma S10 0 protein. The concentration at the end of cardiopulmonary bypass was significantly correlated with plasma inflammatory cytokines. The high concentration of plasma S10 0 protein was in parallel with the inflammatory response 8 h after cardiopulmonary bypass. Conclusion The systemic inflammatory response plays an important role in cardiopulmonary bypass and early postoperative brain injury.