【摘 要】
：
目的 观察维生素A(VA)对碘过量小鼠肝脏胰岛素样生长因子-Ⅰ(IGF-Ⅰ)表达的影响.方法 昆明种小鼠按体质量随机分成6组:对照组(含碘50 μg/L,VA 4000 U/kg);高碘组(含碘3000
【机 构】
：
哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病研究所
【基金项目】
：
国家自然科学基金;黑龙江省自然科学基金
论文部分内容阅读
目的 观察维生素A(VA)对碘过量小鼠肝脏胰岛素样生长因子-Ⅰ(IGF-Ⅰ)表达的影响.方法 昆明种小鼠按体质量随机分成6组:对照组(含碘50 μg/L,VA 4000 U/kg);高碘组(含碘3000 μg/L,VA 4000 U/kg);常碘低VA组(含碘50 μg/L,VA 0 U/kg);高碘低VA组(含碘3000 μg/L,VA 0 U/kg);高碘补VA1组(含碘3000 μg/L,VA 8000 U/kg);高碘补VA2组(含碘3000 μg/L,VA 16 000 U/kg).喂养3、6个月时,ELISA法检测小鼠血清IGF-Ⅰ水平,RT-PCR法检测肝脏IGF-Ⅰ mRNA表达水平.结果 与对照组相比,3个月时各组血清IGF-Ⅰ水平未见明显改变,6个月时高碘组、常碘低VA组、高碘低VA组血清IGF-Ⅰ水平明显下降(q=3.52、3.29、3.84,P＜0.05),高碘补VA组,IGF-Ⅰ水平有所升高,介于对照组和高碘组之间.3、6个月时,高碘和常碘低VA组肝脏IGF-Ⅰ mRNA表达水平,与对照组相比,均有降低趋势;3个月时高碘补VA组与高碘组比较,肝脏IGF-Ⅰ mRNA表达有升高趋势,而6个月时,则未见明显改变,经检验各组差异均无统计学意义(P＞0.05).结论 高碘摄入抑制小鼠肝脏合成分泌IGF-Ⅰ,补充VA可以部分拮抗高碘的抑制作用.
其他文献
目的 研究皮肤肿瘤凋亡抑制基因生存素与人端粒酶逆转录酶(hTERT)的表达及相互关系.方法 免疫组化SP法检测17例鳞状细胞癌(鳞癌)、21例基底细胞癌(基癌)、19例鲍恩病、25例脂
It has been experimentally proved that strain hardening exponent has very strong sensitivity to structure. The measuring result of precise experiment indicated
本文论述了上海市郊区松江新城突进式发展的宏观政治经济背景以及上海“一城九镇”战略决策的形成过程,在对松江新城作了简要剖析之后,指出我国当前大都市效区小城镇的发展过
Based on Petersen graph, a new interconnection network, the RP(k) network, is developed and the properties of the RP(k) network are investigated. The diameter o
For the two fourth-order polynomials a ( s ) and b ( s ), the Hurrwitz stability of their convex combina tion is necessary and snfficient for the existence of a
In this paper, three-dimensional (3D) DEM theory has been explored and applied to impact simulation. The calculated results fit the experimental observation qui
Magnetic refrigeration has drawn much attention because of its greater efficiency and higher reliability than the traditional gas-cycle refrigeration technology
目的 探讨丝裂原激活蛋白激酶类(MAPKs)对缺氧条件下人近端肾小管上皮细胞(HKC)中富含半胱氨酸蛋白61(Cyr61)基因转录活性的调控机制.方法 缺氧培养HKC,Northern印迹检测Cyr6
The space experimental device for testing the Marangoni drop migrations has been discussed in the present paper. The experiment is one of the spaceship projects
We give an overview of the main data of a publication-citation matrix. We show how impact factors are defined,and,in particular,point out the difference between