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生长抑素细胞(D细胞),胃泌素细胞(G细胞),主要分布于胃肠道,尤以胃窦粘膜最多。D细胞分泌的生长抑素(SS)、G细胞分泌的胃泌素,对胃肠功能具有正向或负向调节作用。D、G细胞分泌功能失调,相应的激素水平紊乱,则可导致胃肠功能的障碍。以往的研究表明,脾虚证时,胃肠的功能活动是处于紊乱的病态。因此,探讨脾虚证时D、G细胞的变化,有助于拓展脾虚证实质的内涵。为此。本研究利用大黄塑造的脾虚证大鼠,采用免疫组织化学ABC法,特异性地显示胃窦粘膜D、G细胞,并用医学图象分析系统(MIPS),对D、G细胞进行定量分析。现将研究报告以下。
Somatostatin cells (D cells), gastrin cells (G cells), are mainly distributed in the gastrointestinal tract, especially in the gastric antral mucosa. Secretion of somatostatin (SS) secreted by D cells and gastrin secreted by G cells have a positive or negative regulatory effect on gastrointestinal function. D, G cell secretion dysfunction, the corresponding disorder of hormone levels, can lead to gastrointestinal dysfunction. Previous studies have shown that when the spleen deficiency syndrome occurs, the gastrointestinal function is in a disorderly state. Therefore, to explore the changes of D and G cells in spleen deficiency syndrome, it is helpful to expand the essence of spleen deficiency syndrome. to this end. In this study, the spleen-deficiency syndrome rats modeled by rhubarb were used to specifically display D and G cells in gastric antral mucosa by immunohistochemical ABC method, and D and G cells were quantitatively analyzed by medical image analysis system (MIPS). The study report will now follow.