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目的:探讨卵巢癌超声形态表现与病理,分子生物学之间的相关性。方法:对41例卵巢癌患者术前行超声检查,分析卵巢癌的形态学表现。术后标本行免疫组化染色,测定MMP-3及TIMP-3的表达,并分析与超声表现之间的关系。结果:41例卵巢癌中,肿瘤边界不清,内部回声杂乱伴有腹水的,病理表现为晚期的MMP-3表达最多,而TIMP-3表达最少。结论:卵巢癌超声形态学表现与病理,分子生物学之间存在一定的相关性,可根据其超声形态学表现对癌灶的生物学行为和预后进行评估。
Objective: To investigate the correlation between ultrasound morphological features and pathology and molecular biology in ovarian cancer. Methods: 41 cases of ovarian cancer patients underwent ultrasound examination before operation to analyze the morphological features of ovarian cancer. Postoperative specimens were examined by immunohistochemistry to determine the expression of MMP-3 and TIMP-3, and to analyze the relationship with the ultrasound findings. Results: In 41 cases of ovarian cancer, the tumor boundary was unclear, the internal echo was mixed with ascites, and the pathological manifestation was the expression of MMP-3 and TIMP-3 in the late stage. CONCLUSION: There is a certain correlation between ultrasound morphological features and pathology and molecular biology in ovarian cancer. The biological behavior and prognosis of ovarian cancer can be evaluated according to their morphological features.