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目的 探讨影响重型肝炎、活动性肝硬化患者医院感染预后的危险因素及其防治措施。方法 前瞻性调查 1996年 4月至 2 0 0 0年 12月住院的重型肝炎、活动性肝硬化患者医院感染情况并进行统计分析。结果 重型肝炎、活动性肝硬化医院感染病死率为 37 36 % (34/ 91) ,单因素分析表明血清胆红素、PT、补体C3、血清胆固醇、血钠、白细胞总数、中性粒细胞比例、感染类型、并发症种类、侵袭性操作与预后有相关性 ,多因素分析表明低补体C3及低胆固醇预后严重不良。结论 医院感染是导致重型肝炎、活动性肝硬化患者死亡的重要因素 ,血清低补体C3及低胆固醇是影响预后的高危因素。
Objective To explore the risk factors of nosocomial infection affecting patients with severe hepatitis and active cirrhosis and the preventive measures. Methods A prospective investigation was conducted on the prevalence of nosocomial infections in patients with severe hepatitis and active cirrhosis between April 1996 and December 2000. Results The mortality of severe hepatitis and active cirrhosis was 37 36% (34/91). Univariate analysis showed that serum bilirubin, PT, complement C3, serum cholesterol, serum sodium, total white blood cells, neutrophil ratio , Type of infection, types of complications, invasive procedures and prognosis, multivariate analysis showed that low complement C3 and low cholesterol serious prognosis. Conclusion Hospital infection is an important factor leading to death of patients with severe hepatitis and active cirrhosis. Serum low complement C3 and low cholesterol are the risk factors of prognosis.