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目的:观察染料木黄酮(GST)延缓女性更年期的临床疗效和安全性,探讨其作用机制。方法:将选择好的受试者随机分为GST、ISO组和安慰剂对照组,各组按规定服用试验胶囊,试验前后进行改良Kapperman评分和各项指标检测,统计更年期相关疾病发生率,所得数据进行多元逐步回归及方差分析比较。结果:GST、ISO组的临床症状较试验前有显著改善(P<0.01)和有所改善(P<0.05),性激素基本恢复到正常水平和有所恢复,两组均无明显不良反应;安慰剂组的临床症状较试验前更加严重,激素更加偏离正常水平,相关疾病发生率>GST和ISO组。结论:GST能延缓更年期,可减少相关疾病的发生率,疗效确切、安全,其延缓更年期的机制可能与其雌激素效应有关。
Objective: To observe the clinical efficacy and safety of genistein (GST) in delaying female menopause and to explore its mechanism. Methods: The selected subjects were randomly divided into GST, ISO group and placebo control group, each group taking the test capsule as required, before and after the test improved Kapperman score and the detection of indicators, statistical incidence of menopause-related diseases, the income Data were subjected to multiple stepwise regression and analysis of variance. Results: The clinical symptoms in GST group and ISO group were significantly improved (P <0.01) and improved compared with that before test (P <0.05), while the sex hormones returned to normal level and recovered with no apparent adverse reactions in both groups; The clinical symptoms of the agent group were more serious than those before the test, and the hormones were deviated from the normal level. The incidence of related diseases was> GST and ISO group. Conclusion: GST can delay menopause, reduce the incidence of related diseases, the curative effect is exact and safe, and its mechanism of delaying menopause may be related to its estrogen effect.