非洲裔美国人体内普遍存在低密度脂蛋白基因

• 作 者: 刘耀辉
• 出 处: 国外医学情报
• 发表日期: 2005年05期
• 关键词: 非洲裔美国人 低密度脂蛋白 实验小鼠 总胆固醇水平 基因突变 胆固醇 变异 关联 变异基因 近期出版

近日,研究人员鉴定出2种常见于非洲裔美国人个体中的遗传性基因突变,该基因的突变与50％的低密度脂蛋白(坏的)胆固醇的减少相关联;而以往实验小鼠的研究显示一种被称为PCSK9基因的另一种突变可因其低密度脂蛋白水平升高而导致小鼠的总胆固醇水平提高。为了验证PCSK9基因变异是否能引起相反的结

Recently, the researchers identified two genetic mutations commonly found in African-American individuals whose mutations were associated with a 50% reduction in low-density lipoprotein (bad) cholesterol; whereas in the past experimental mice Studies have shown that another mutation, called the PCSK9 gene, can lead to an increase in total cholesterol levels in mice due to its elevated levels of low-density lipoproteins. In order to verify whether PCSK9 gene mutation can cause the opposite junction