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目的探讨单核细胞计数与冠状动脉扩张性病变(CAE,coronary artery ectasia)的关联。方法采用回顾性病例对照的研究设计,病例组由阻塞性冠状动脉疾病(O-CAD,obstructive coronary artery disease)合并CAE患者组成,利用倾向性评分的方法 ,为病例组匹配出由单纯O-CAD患者构成的对照组。结果病例组和对照组各有619例患者。与单纯O-CAD患者相比,O-CAD合并CAE患者单核细胞显著升高{0.45(0.35;0.57)×109/L vs.0.43(0.33;0.54)×109/L,P=0.002},多因素Logistic回归分析显示单核细胞和CAE独立相关(比值比=1.39,95%置信区间:1.07-1.79,P=0.013)。在男性亚组中,O-CAD合并CAE患者单核细胞水平高于单纯O-CAD患者。结论 O-CAD合并CAE患者单核细胞水平显著高于单纯O-CAD患者,单核细胞计数与CAE独立相关。
Objective To investigate the relationship between monocyte count and coronary artery ectasia (CAE). Methods A retrospective case-control study was designed. The case group consisted of obstructive coronary artery disease (O-CAD) and CAE patients. The propensity score method was used to match the cases with O-CAD Patient composition of the control group. Results There were 619 patients in each case and control group. Compared with patients with O-CAD alone, monocytes in patients with O-CAD and CAE were significantly increased (0.45 (0.35; 0.57) × 109 / L vs 0.43 (0.33; 0.54) × 109 / L, P = 0.002} Multivariate Logistic regression analysis showed that monocytes were independently associated with CAE (odds ratio = 1.39, 95% confidence interval: 1.07-1.79, P = 0.013). In the male subgroup, monocyte levels were higher in patients with O-CAD and CAE than in patients with O-CAD alone. Conclusions Monocyte levels in patients with O-CAD and CAE are significantly higher than those in patients with O-CAD alone, and monocyte counts are independently associated with CAE.