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端粒酶(telomerase)与胃癌发生发展的关系是近年来肿瘤分子生物学研究的热点.幽门螺杆菌(Helicobacter pylori,Hp)感染与胃癌发生可能有相关性.现就端粒酶、幽门螺杆菌及胃癌三者间的相互关系进行探讨.1端粒、端粒酶与胃癌1.1端粒是位于真核生物细胞染色体未端的特殊结构,由DNA 和蛋白质构成,其 DNA 是富含 TTAGGG 碱基对的分子内简单重复序列.这种重复序列的碱基组成及长度因物种而异,其主要功能有两个,防止染色体未端核酸外切酶降解及染色体之间的端端融合,是染色体正确复制和细胞生存的基础.能防止染色体 DNA在复制过程中的不断丢失,有效地
The relationship between telomerase (telomerase) and the development of gastric cancer is a hot research topic in molecular biology of cancer in recent years.Helicobacter pylori (Hp) infection may have a correlation with the occurrence of gastric cancer.However, telomerase, Helicobacter pylori And gastric cancer.1 Discussion of Telomere, Telomerase and Gastric Cancer 1.1 Telomeres are special structures located at the end of chromosomes of eukaryotes and consist of DNA and protein. The DNA is rich in TTAGGG base pairs Of the simple repeat within the sequence of this repeat base composition and length varies by species, its main function of two, to prevent the degradation of exonuclease and chromosomal end-end fusion between the chromosome is correct The basis of replication and cell survival. Can prevent the constant loss of chromosomal DNA in the replication process, effectively