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目的 探讨法洛四联症 (TOF)患儿心肌细胞钙运转与心功能的关系。方法 钙荧光指示剂Fura - 2法测定心肌细胞游离钙浓度 ,HP - 10 0 0型超声心动图机测定心功能。结果 2 8例TOF患儿红细胞游离钙和总钙浓度较健康组明显高 ,而钙泵活性明显低下 ;其中 8例舒张功能正常者红细胞钙泵活性与健康组无差别 ,而 2 0例舒张功能异常者不仅钙泵和钠泵活性较舒张功能正常者明显下降 ,且红细胞游离钙和总钙浓度亦较舒张功能正常者升高。结论 TOF患儿心肌细胞内钙运转与其心肌舒张功能异常密切相关。
Objective To investigate the relationship between cardiomyocyte calcium turnover and cardiac function in children with tetralogy of Fallot (TOF). Methods Calcium fluorescence indicator Fura - 2 was used to measure the free calcium concentration of cardiomyocytes. The heart function was determined by HP - 100 echocardiography. Results Erythrocyte free calcium and total calcium concentrations in 28 children with TOF were significantly higher than those in healthy controls and calcium pump activity was significantly lower. Among them, 8 patients with normal diastolic function had no difference in erythrocyte calcium pump activity, while 20 patients had diastolic function Abnormalities not only calcium pump and sodium pump activity than normal diastolic function decreased significantly, and red blood cell calcium and total calcium concentrations than normal diastolic function increased. Conclusion The intracellular Ca2 + transport in TOF children is closely related to the abnormal myocardial diastolic function.