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目的 观察单独使用瑞易宁或瑞易宁联合二甲双胍 (瑞易宁 /联合二甲双胍 )治疗 2型糖尿病病人的有效性、安全性及可行性。方法 1 2 6例门诊 2型糖尿病患者 ,平均体重指数BMI为 2 5 1kg/m2 ,平均年龄 5 3 6岁 ,6 5岁以上的老年患者有 4 0例 (32 % )。 77例 (6 1 % )为空腹血糖很高的新诊 2型糖尿病患者 ,4 9例 (39% )既往曾用非瑞易宁口服降糖药治疗但血糖控制不佳 ,平均病程 7 2年。接受瑞易宁 /联合二甲双胍治疗时间平均半年以上 (0 3～ 2 2年 ) ,检测空腹血糖 (FPG)和体重变化 ,了解低血糖事件及患者自觉健康状况改善情况。结果 经瑞易宁 /联合二甲双胍治疗后 ,患者血糖得到明显改善。其中新诊 2型糖尿病患者FPG由 (1 1 7± 3 0 )mmol/L降至 (6 8± 1 8)mmol/L(P <0 0 0 1 ) ,既往曾用口服降糖药治疗患者FPG由 (8 8± 2 6 )mmol/L降至 (7 3± 2 1 )mmol/L(P <0 0 1 ) ,两组病人治疗后空腹血糖达标率 (系指FPG≤ 7 0mmol/L)分别为 88% (P <0 0 0 1 )和 6 3%(P <0 0 0 1 ) ,体重平均下降 3 8kg和 0 9kg,轻度低血糖反应有 7例 (5 6 % ) ,96人 (76 % )自觉健康状况改善 ,1 0 2人 (81 % )对瑞易宁 /联合二甲双胍治疗满意并愿意长期使用。结论 瑞易宁 /联合二甲双胍治疗 2型糖尿病是有效?
Objective To observe the efficacy, safety and feasibility of treating patients with type 2 diabetes mellitus with rivaginin alone or in combination with metformin (rilene and metformin). Methods One hundred twenty-six outpatients with type 2 diabetes mellitus had an average body mass index (BMI) of 251 kg / m2 with a mean age of 536 years and 40 (32%) elderly patients over 65 years of age. Forty-seven patients (61%) were newly diagnosed type 2 diabetic patients with fasting blood glucose. Forty-nine patients (39%) were previously treated with felreciplined oral hypoglycemic agents but had poor glycemic control with an average duration of 72 years . The average duration of treatment with regimen / metformin was over half a year (range, 0-3 to 22 years). Fasting plasma glucose (FPG) and body weight were measured to understand the incidence of hypoglycaemia and the improvement of patients’ self-conscious health status. Results Rui Yi Ning / metformin treatment, the patient’s blood glucose was significantly improved. FPG in newly diagnosed type 2 diabetic patients dropped from (11 7 ± 30) mmol / L to (6 8 ± 1 8) mmol / L (P 0 01). Previously, patients treated with oral hypoglycemic agents The FPG decreased from (8 8 ± 2 6) mmol / L to (73 ± 2 1) mmol / L (P 0 01). The fasting blood glucose (FPG) ) Were 88% (P 0 01) and 63% (P 0 01) respectively. The average weight loss was 38kg and 0 9kg respectively. There were 7 cases (56%) with mild hypoglycemia and 96 One (76%) consciously improved their health, and 102 (81%) were satisfied and were prepared for long-term use of revanen / metformin. Conclusions Rebining / metformin is effective in treating type 2 diabetes mellitus?