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2 溴 1 对甲氧基苯丙酮与对甲氧基苯乙胺反应后 ,再经脱二甲基和硼氢化钾还原 ,合成了利托君。中间体 1 (4 甲氧基苯基 ) 2 [2 (4 甲氧基苯基 )乙胺基 ]丙 1 酮盐酸盐(5 )为新化合物 ,结构经ＭＳ、1ＨＮＭＲ证实。以 2 溴 1 对甲氧基苯丙酮计算 ,总收率为 2 8 6 %。利
2 bromo-1-methoxy-2-propiophenone and p-methoxy phenethylamine reaction, and then by dimethyl and potassium borohydride reduction, the synthesis of ritodrine. The intermediate 1 (4 methoxyphenyl) 2 [2 (4 methoxyphenyl) ethylamino] propanone hydrochloride (5) is a new compound whose structure has been confirmed by MS and 1H NMR. The total yield was 286% calculated on 2-bromo-1-methoxyphenylacetone. Lee