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目的阐明补脾散对溃疡性结肠炎的治疗作用．方法溃疡性结肠炎１１６例，用自拟补脾散３０ｇ，加开水１５０ｍｌ混匀后保留灌肠，每晚１次；另５ｇ内服，１～３次／ｄ．疗程１个月，用１～３个疗程．对用乙酸造成的溃疡性结肠炎大鼠模型用此治疗进行监测，并用柳氮磺吡啶（对照组）及生理盐水（空白对照组）进行药效实验及毒理实验．结果补脾散治疗溃疡性结肠炎１１６例，治愈１０７例（９２２％），好转９例（７８％）．对治愈的５５例随访６个月～１０年．６个月内复发３例（５５％），缓解１年以上４４例（８００％），缓解３年以上３４例（６１８％），缓解５年以上１０例（１８２％）．对用乙酸造成的溃疡性结肠炎大鼠模型，用此法治疗，中剂量和大剂量组优于对照组柳氮磺吡啶，经毒性实验未见毒性改变．结论补脾散治疗溃疡性结肠炎疗效高，无毒副作用，且远期疗效好．
Objective To elucidate the therapeutic effect of Bupi San on ulcerative colitis. Methods 116 cases of ulcerative colitis, with self-made spleen scattered 30g, add boiling water 150ml after mixing enema retention, 1 night; the other 5g orally, 1 to 3 times / d. Course of 1 month, with 1 to 3 courses. The rat model of ulcerative colitis induced by acetic acid was monitored with this treatment. The pharmacodynamic and toxicological experiments were conducted with sulfasalazine (control group) and normal saline (blank control group). Results Bu Pi San treatment of ulcerative colitis in 116 cases, 107 cases were cured (92 2%), improved in 9 cases (7 8%). The 55 cases were followed up for 6 months to 10 years. 3 cases (55%) relapsed within 6 months, 44 cases (800%) relieved more than 1 year, 34 cases (618%) relieved more than 3 years and 10 cases (5 5 years) %). For acetic acid induced ulcerative colitis rat model, with this method of treatment, medium dose and high dose group is superior to the control group sulfasalazine, toxicity test showed no toxicity change. Conclusion Bu Pi San for the treatment of ulcerative colitis with high efficacy, no toxic side effects, and good long-term efficacy.