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This study investigated the expression and prognostic value of SHP-2 in cervical cancer caused by human papillomavirus (HPV) infection.Forty-five specimens from patients with cervical cancer (stage Ⅰ -Ⅲ),32 specimens from patients with cervical intraepithelial neoplasia (CIN) ( Ⅰ,Ⅱ) and 20 normal cervical samples from patients with hysteromyoma were collected in Department of Pathology for comparison.The expression levels of SHP-2 and IFN-β proteins were detected by using immunohistochemistry.The mRNA expression level of SHP-2 was detected by using quantitative real-time polymerase chain reaction (PCR).HPVs were detected by HPV GenoArray Test.The Spearman correlation was used to compare the expression level of SHP-2 in HPV infected cervical cancer vs non-HPV infected normal cervix.The level of SHP-2 protein expression in the cancer tissues (88.8％) was significantly higher than in CIN tissues (62.5％) and normal cervixes (45％) (P＜0.05 and P＜0.05,respectively).The SHP-2 mRNA levels in the cancer tissues were upregulated as compared with those in the normal cervixes (P＜0.05).Twenty-one (46.7％) cervical cancers,25 (78.1％) CINs and 17 (85％) normal cervixes showed IFN-β positive staining in cytoplasm.There was statistically significant difference in the expression rate of IFN-β between cervical cancer and normal cervix (x2=8.378,P＜0.05) as well as between cervical cancer and CIN (x2=7.695,P＜0.05).HPV16/18 infections could be found in normal cervixs (15％),CINs (68.7％) and cervical cancers (84.4％).There was a correlation between HPV infection and SHP-2 expression in cervical cancer (rs=0.653,P＜0.05).SHP-2 may be a useful prognostic and diagnostic indicator for HPV infected cervical cancer.In cervical canccrs,SHP-2 mRNA and protein overexpression was associated with IFN-β lower-expression.