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机体的内部平衡及脏器结构功能的稳定有赖于细胞之间及细胞与外环境的相互作用,通过粘合与信号转导对细胞表型与行为进行社会性调控.细胞粘合的分子基础——粘合分子受体,以钙粘蛋白和整合蛋白的分布最为广泛.这类分子为跨膜的糖蛋白,其分子的胞质内域与膜内面多种蛋白质结成分子链式复合体,并与细胞骨架相连,在组织细胞间或细胞与外基质间形成具备粘合与信号转导双重功能的网络体系,参与调节组织发生和形态分化,对细胞识别、迁移、归类等行为及细胞发育的命运起到重要作用,与细胞功能的调控及疾病发生有着密切的关系.某些整合蛋白有抑癌基因特性.整合蛋白形成的焦点接触分子链中有些成员既是微丝骨架结合蛋白,又是整合蛋白受体启动的信号途径中磷酸激酶的作用底物,具有信号中转的作用.其中有的分子具备抑癌基因的特性.钙粘蛋白相关的膜内粘着分子β-Catenin是癌基因Wnt信号通路中的成员.E-Cadherin在多种上皮型癌的表达下降.E-Cadherin和Catenin分别有抗侵润和抗转移抑癌基因的作用.钙粘蛋白的表达对间隙连接基因Connexin在转译后的功能表达有重要性,发育生物学和癌细胞表型分化调节的证据提示两者介导的信号途径之间存在某种内在的平衡关系.
The internal balance of the body and the stability of the organ structure depend on the interaction between cells and cells and the external environment, and regulate the phenotype and behavior of cells through adhesion and signal transduction. The molecular basis of cell adhesion is— - Adhesion molecule receptors, the most widely distributed cadherins and integrins. This type of molecule is a transmembrane glycoprotein, its molecular cytoplasmic domain and a variety of protein components within the membrane sub-chain complexes, It is connected to the cytoskeleton and forms a network system with dual functions of adhesion and signal transduction between tissue cells or between cells and the outer matrix. It is involved in the regulation of tissue formation and morphological differentiation, as well as cell recognition, migration, classification and other behaviors and cell development. The fate plays an important role and is closely related to the regulation of cell function and the occurrence of diseases. Some integrins have the characteristics of tumor suppressor genes. Some members of the focal contact molecule chain formed by integrins are both microfilament skeleton binding proteins, and The substrate for the action of phosphokinase in the integrin receptor-initiated signaling pathway has the function of signal transduction. Some of these molecules possess the characteristics of tumor suppressor genes. White-related membrane adhesion molecule β-Catenin is a member of the oncogene Wnt signaling pathway. The expression of E-Cadherin in many epithelial cancers is decreased. E-Cadherin and Catenin have anti-invasion and anti-metastasis genes, respectively. Role. The expression of cadherin plays an important role in the expression of gap junction gene Connexin after translation. Evidence of developmental biology and regulation of cancer cell phenotypic differentiation suggests that there is an inherent balance between the signal pathways mediated by the two. relationship.