Hepatitis C Virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuc

• 作 者: Guo-Zhong Gong Jie Cao Yong-Fa
• 机 构: InstituteofHepatologyandDepartmentofInfectiousDiseases
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2007年30期
• 关键词: 丙肝病毒 蛋白质 磷酸化 转移 Hepatitis C virus nonstructural protein 5A IFN-α Signal transd
• 基金项目: Supported by National Natural Science Foundation of China, No. 39670671, No. 30471531,ACKN0WLEDGMENTS We wish to thank Drs. Xian-Shi Su, Xin-Xiang Xiao, Wen- Long Wang and Chun-Ming Deng for their tec

AIM: To study the effect of Hepatitis C virus non- structural 5A (HCV NS5A) on IFNα induced signal transducer and activator of transcription-1 (STAT1) phosphorylation and nuclear translocation. METHODS: Expression of STAT1 Tyr701 phosphorylation at differ