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本实验用麻醉大鼠冠状动脉左前降支结扎方法,研究了牛磺酸、艾司洛尔两药单用及合用的抗缺血性心律失常作用。结果表明,牛磺酸70mg·kg~(-1),140mg·kg~(-1)可使心律失常发生时间推迟,减少重性早博(PVCs)次数,缩短室性心动过速(VT)、心室纤颤(VF)累计持续时间并降低其发生率,恢复窦律时间提前。艾司洛尔25mg·kg~(-1)推迟心律失常发生时间,缩短VT累计持续时间,降低VF发生率.牛磺酸70mg·kg~(-1)与艾司洛尔25mg·kg~(-1)合用,其抗心律失常效果较单用增强。血流动力学实验结果表明.两药合用较艾司洛尔单用对心缩力的抑制减弱。离体大鼠心脏用牛磺酸40mmol·L~(-1)灌流后,抑制苯肾上腺素对心脏的正性肌力和正性频率作用。
In this study, anesthetized rats with left anterior descending coronary artery ligation method to study the taurine, esmolol single and combined anti-ischemic arrhythmia. The results showed that taurine 70 mg · kg -1 and 140 mg · kg -1 delayed the arrhythmia, decreased the number of PVCs and shortening ventricular tachycardia (VT) , Ventricular fibrillation (VF) cumulative duration and reduce the incidence of recovery sinus time ahead of schedule. Esmolol 25 mg · kg -1 delayed the time of arrhythmia, shortened the cumulative duration of VT and decreased the incidence of VF.Conclusion Taurine 70 mg · kg -1 and esmolol 25 mg · kg ~ (-1) -1) combination, the anti-arrhythmic effect than single use enhanced. Hemodynamic test results show that the two drugs combined with esmolol single inhibition of cardiac contractility weakened. After the heart of isolated rat was perfused with 40 mmol·L -1 of taurine, the positive inotropic and positive frequency of phenylephrine was inhibited.