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阐明四氢原小檗碱同类物（ＴＨＰＢ）对大鼠中脑腹侧被盖区（ＶＴＡ）多巴胺（ＤＡ）受体的作用特性，并比较它们的作用强度．方法：采用大鼠在体胞外单位放电记录．结果：观察了１１个ＴＨＰＢ均可完全地翻转ＤＡ受体激动剂阿扑吗啡（２０μｇ·ｋｇ－１）所产生的放电抑制作用，为Ｄ２受体拮抗剂的作用特性．ＴＨＰＢ对Ｄ２受体的作用与Ｃ２位上的ＯＨ基团有密切的关系．它们的作用强度（ＥＤ５０，μｇ·ｋｇ－１）：ＴＨＰＢ１４３（５６）＞ＳＰＤ（８５）＞Ｉｓｏ（１７０）＞ＴＨＰ（３３）＞ＴＨＢ（４８）＞ＴＨＰＢ１８（６６）＞ＴＨＰＢ１（１７９）＞ＴＨＰＢ１９（４０８）＞ＴＨＰＢ１２６（５１０）＞ＴＨＰＢ１０４（１０１９）＞ＴＨＰＢ１０（４８１５）．结论：１１个ＴＨＰＢ均为ＶＴＡＤ２受体拮抗剂，以Ｃ２位上有ＯＨ基团的ＴＨＰＢ１４３作用最强．
To elucidate the effects of tetrahydroprotoberberine (THPB) on dopamine (DA) receptors in the ventral tegular area of rats (VTA) and to compare their effects. Methods: Discharge recorded in extracellular units of rats. RESULTS: Eleven THPBs were able to completely reverse the inhibitory effect of dopamine apomorphine (20 μg · kg -1) on D2 receptor antagonist. The effect of THPB on D2 receptors is closely related to the OH group at C2. (ED50, μg · kg-1): THPB143 (5.6)> SPD (8.5)> Iso (170)> THP (33)> THB (48)> THPB18 (66)> THPB-1 (179)> THPB-19 (408)> THPB-126 (510)> THPB-104 (1019)> THPB-10 (4815). CONCLUSIONS: Eleven THPBs are all VTAD2 receptor antagonists, and THPB-143, which has an OH group on C2 site, has the strongest effect.