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Acute myocardial ischaemia is a common acutedisease and a common cause of sudden death.However,it is difficult to diagnose in patients who diedwithin 6 hours after the onset of myocardial ischaemia.The occurrence of sudden cardiac death often haspathological basis of primary heart diseases,which maylead to a series of changes in metabolism and geneexpression.Recent research found that hypoxia induciblefactor 1 alpha (HIF-1α) is a sensitive marker of hypoxia;its gene expression is upregulated within several minutesafter acute myocardial ischaemia,followed by the
Acute myocardial ischaemia is a common acutedisease and a common cause of sudden death.However, it is difficult to diagnose in patients who diedwithin 6 hours after the onset of myocardial ischaemia. The occurrence of sudden cardiac death often haspathological basis of primary heart diseases, which maylead to a series of changes in metabolism and gene expression. Research has shown that hypoxia inducible factor 1 alpha (HIF-1α) is a sensitive marker of hypoxia; its gene expression is upregulated within several minutes after acute myocardial ischaemia, followed by the