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Objective To investigate the occurrence of nocturnal myocardial ischemia and its relationship with sleep-disordered breathing(apneas and oxygen desaturations)in patients with angina pectoris undergoing coronary an-giography.Methods Eighty-two men and 14 women referred for consideration of coronary intervention wererandomly selected.Observation by an overnight sleep monitor and Holter recording were performed to studysleep-disordered breathing(oxyhemoglobin desaturations≥4% and apnea-hypopneas),heart rates,and ST-seg-ment depressions(≥1mm,≥1 min).Results Nocturnal ST-segment depressions occurred in 37% of thepatients.ST-segment depression within 2 min after an apnea-hypopnea or desaturation occurred in 17% of thepatients.This temporal association was seen in 21% of the patients with nocturnal ST-segment depressions,morefrequendy in men(P<0.05)and more frequently in those with severe disordered breathing(P<0.05).Mostof these ST-segment depressions were preceded by a series of breathing events:repeated apnea-hypopneas or de-saturations or both in 73% of the patients.Conclusions Episodes of nocturnal myocardial ischemia are com-mon in patients with angina pectoris.A temporal relationship between sleep-disordered breathing and myocardialischemia was present in some of our patients,and occurs more frequently in men and in those with severely dis-ordered breathing.(J Geriatr Cardiol 2004;1(2):90-94.)
Objective To investigate the occurrence of nocturnal myocardial ischemia and its relationship with sleep-disordered breathing (apneas and oxygen desaturations) in patients with angina pectoris undergoing coronary an-giography. Methods Eighty-two men and 14 women referred for consideration of coronary intervention wererandomly selected .Observation by an overnight sleep monitor and Holter recording were performed to studysleep-disordered breathing (oxyhemoglobin desaturations ≥ 4% and apnea-hypopneas), heart rates, and ST-seg ment depressions (≥1 mm, ≥1 min). Results Nocturnal ST-segment depressions occurred in 37% of the patients. ST-segment depression within 2 min after an apnea-hypopnea or desaturation occurred in 17% of the patients. This temporal association was seen in 21% of the patients with nocturnal ST-segment depressions, morefrequendy in men (P <0.05) and more frequently in those with severe disordered breathing (P <0.05) .Most of these ST-segment depressions were preceded by a series of breat hing events: repeated apnea-hypopneas or de-saturations or both in 73% of the patients. Conclusions Episodes of nocturnal myocardial ischemia are com-mon in patients with angina pectoris. A temporal relationship between sleep-disordered breathing and myocardialischemia was present in some of our patients, and occurs more frequently in men and in those with severely dis-ordered breathing. (J Geriatr Cardiol 2004; 1 (2): 90-94.)