论文部分内容阅读
儿茶酚胺多聚体之衍生物LICAM(C)是一种新型络合剂,它对钚(Ⅳ)有特殊的络合能力。实验证明,LICAM(C)对清除小鼠或小猎犬的钚,比单用CaNa_3-DTPA更有效。本实验是在放射性核素业已牢固地沉积在组织中后,用LICAM(C)和DTPA重复治疗,以判别两者的相对促排效果。实验中用DTPA锌盐取代钙盐以避免反复注射DTPA钙盐所导致的毒性副作用。实验用四只青壮龄小猎犬,单次静注~(241)镅、~(239)钚和光辐射体~(237)钚的柠檬酸盐液。两周后,取其中两只每天皮下注射30μmol·kg~(-1)Zn-DTPA,另外两只则注射30μmol·kg~(-1)LICAM(C),14
LICAM (C), a derivative of catecholamine multimers, is a novel complexing agent that has a special ability to complex plutonium (IV). Experiments show that LICAM (C) is more effective in clearing plutonium from mice or beagle dogs than CaNa_3-DTPA alone. In this experiment, after radionuclide has been firmly deposited in the tissue, repeated treatment with LICAM (C) and DTPA is performed to determine the relative promoting effect of both. DTPA zinc salts were substituted for calcium salts in the experiment to avoid toxic side effects caused by repeated injections of DTPA calcium salts. Four young brackish beagle dogs were experimentally injected with ~ (241) 镅, ~ (239) plutonium and ~ (237) plutonium citrate. Two weeks later, two subcutaneous injections of 30 μmol · kg -1 Zn-DTPA and 30 μmol · kg -1 LICAM (C) and 14